Transitional B cell cytokines predict renal allograft outcomes
نویسندگان
چکیده
A low transitional-1 B cell IL-10/TNF? ratio predicts rejection and supports preemptive intervention for patients after kidney transplantation.
منابع مشابه
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متن کاملReduced human transitional B cell T1/T2 ratio is associated with subsequent deterioration in renal allograft function.
Human transitional B cells express relatively high IL-10 and low TNF-α levels, which correlate with B regulatory activity in vitro. Herein, we aim to further define B regulatory phenotype and determine whether B regulatory activity can serve as a prognostic marker for renal allograft dysfunction (graft loss or 2-fold fall in estimated glomerular filtration rate). Transitional B cells can be div...
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OBJECTIVES Our objective was to determine the incidence and outcomes of renal cell carcinoma and transitional cell carcinoma in recipients of renal allografts. MATERIALS AND METHODS We analyzed data from 2000 to 2012 in the Australia and New Zealand Dialysis and Transplant Registry, a binational population-based database, to identify the incidence and survival outcomes of renal transplant rec...
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A major problem in renal transplantation is identifying a grading system that can predict long-term graft survival. The present study determined the extent to which the two existing grading systems (Banff 97 and chronic allograft damage index, CADI) correlate with each other and with graft loss. A total of 161 transplant patient biopsies with chronic allograft nephropathy (CAN) were studied. Th...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2021
ISSN: ['1946-6242', '1946-6234']
DOI: https://doi.org/10.1126/scitranslmed.abe4929